Publications - Delphinus Medical Technologies

Scientific Support

Delphinus can boast of a well-respected team of scientists who developed SoftVue™ and continue to advance ultrasound science. They are widely published and recognized as leaders within the scientific community. Co-founders Peter Littrup, MD and Neb Duric, PhD were named Innovators of the Year by MichBio in 2011 and praised by Governor of Michigan, Rick Snyder, for their innovative cancer research. The entire scientific team continues to expand fields of study, including a large body of clinical and scientific work listed below. Each listing is linked to the available abstract or manuscript.

Clinical Studies

Scientific Studies

- Tissue Characterization With Ultrasound Tomography Machine Learning

- 3D frequency-domain ultrasound waveform tomography breast imaging

- Image reconstruction for ultrasound computed tomography by use of the regularized dual averaging method

- A comparison of automated versus manual segmentation of breast UST transmission images to measure breast volume and sound speed

- Frequency Domain Ultrasound Waveform Tomography: Breast Imaging using a Ring Transducer

- Image fusion of Ultrasound Computer Tomography Volumes with X-ray Mammograms using a Biomechanical Model Based 2D/3D Registration

- Breast Ultrasound Computed Tomography using Waveform Inversion with Source Encoding

- High-Resolution Quantitative Whole-Breast Ultrasound: In Vivo Application using Frequency-Domain Waveform Tomography

- Waveform Inversion with Source Encoding for Breast Sound Speed Reconstruction in Ultrasound Computed Tomography

- Breast Boundary Detection with Active Contours

- Comparison of Sound Speed Measurements on Two Different Ultrasound Tomography Devices

- Toward a Practical Ultrasound Waveform Tomography Algorithm for Improving Breast Imaging

- Sound speed based patient-specific biomechanical modeling for registration of USCT volumes with X-ray mammograms

- Characterization of human breast cancer by scanning acoustic microscopy

- Resolution limitation of travel time tomography: beyond the first Fresnel zone

- Automatic multimodal 2D/3D image fusion of Ultrasound Computer Tomography and X-ray mammography for breast cancer diagnosis

- Combining time of flight and diffraction tomography for high resolution breast imaging: Initial in vivo results (L)

- Multi-grid tomographic inversion for breast ultrasound imaging

- Travel Time Denoising in Ultrasound Tomography

- 2D/3D Image Fusion of X-ray Mammograms with Speed of Sound Images: Evaluation and Visualization

- Comparison of 3D and 2D Breast Density Estimation from Synthetic Ultrasound Tomography Images and Digital Mammograms of Anthropomorphic Software Breast Phantoms

- Double difference tomography for breast ultrasound sound speed imaging

- In-vivo imaging of breast cancer with ultrasound tomography: Probing the tumor environment

- Modification of Kirchhoff migration with variable sound speed and attenuation for acoustic imaging of media and application to tomographic imaging of the breast

- Relationship between breast sound speed and mammographic percent density

- Robust Array Calibration using Time Delays with Application to Ultrasound Tomography

- Modification of Kirchhoff migration with variable sound speed and attenuation for tomographic imaging of the breast.

- Breast Tissue Composition and Susceptibility to Breast Cancer

- In-vivo imaging results with ultrasound tomography: Report on an ongoing study at the Karmanos Cancer Institute

- Registration of X-ray mammograms and three-dimensional speed of sound images of the female breast

- An improved automatic time-of-flight picker for medical ultrasound tomography

- Breast ultrasound tomography with total-variation regularization

- Diffraction and coherence in breast ultrasound tomography: A study with a toroidal array

- In Vivo Breast Sound-Speed Imaging with Ultrasound Tomography

- Temperature monitoring during tissue freezing using ultrasound speed measurements

- A study of 3-way image fusion for characterizing acoustic properties of breast tissue

- Breast Imaging Using Transmission Ultrasound: Reconstructing Tissue Parameters of Sound Speed and Attenuation

- Clinical breast imaging using sound-speed reconstructions of ultrasound tomography data

- Comparison of ultrasound attenuation tomography methods for breast imaging

- Frequency Diversity in Breast Ultrasound Tomography

- Globally optimized Fourier finite-difference method for ultrasound breast imaging

- Ultrasound Pulse-Echo Imaging with an Optimized Propagator

- Transmission and Reflection Diffraction Tomography in Breast Imaging

- Multi-modal breast imaging with ultrasound tomography

- A new method for quantitative analysis of mammographic density

- Imaging beyond the Born approximation: An experimental investigation with an ultrasonic ring array

- Novel approach to evaluating breast density utilizing ultrasound tomography

- Sound-speed tomography using first-arrival transmission ultrasound for a ring array

- Breast imaging with time-reversed ultrasound

- Development of ultrasound tomography for breast imaging: Technical assessment

- Ultrasonic breast imaging using a wave-equation migration method

- Ultrasound Tomography of Breast Tissue

- A comparison of ultrasound tomography methods in circular geometry

- Characterizing tissue with acoustic parameters derived from ultrasound data

- Computerized Ultrasound Risk Evaluation (CURE) System: Development of Combined Transmission and Reflection Ultrasound with New Reconstruction Algorithms for Breast Imaging

- Ultrasound imaging using diffraction tomography in a cylindrical geometry
- Using Data Fusion to Characterize Breast Tissue